Dr. Jonathan P. Riley

Jonathan P. Riley

, MD

Dr. Riley is an Assistant Professor of Neurosurgery at the State University of New York (SUNY) at Buffalo, having joined in Fall 2017. Dr. Riley is the Medical Director of Functional Neurosurgery and Fellowship Director for the Stereotactic & Functional Neurosurgery fellowship position. After receiving a Bachelors of Science in Engineering from Mercer University in 2000, Dr. Riley completed medical school at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (2009), simultaneously obtaining a Masters of Science in Pathology. He went on to complete his neurosurgical residency at Emory University (2016).

During his neurosurgical residency, he completed an enfolded Stereotactic and Functional Neurosurgery Fellowship and completed a post-residency Fellowship position in the same at Thomas Jefferson University Hospital.

Dr. Riley placed emphasis on this subspecialized training to be best positioned to provide a full range of surgical treatment options to patients with afflictions affecting the function of the central nervous system. These include surgical treatments for the broad spectrum of Movement Disorders, epilepsies, pain syndromes, and emerging psychiatric indications.

Throughout medical school and residency, Dr. Riley has meaningfully and longitudinally participated in translational and clinical research agendas. These have included both small and large animal work and have focused on the clinical translation of biologics-based therapeutics with an emphasis on development of approaches to therapeutics delivery to the central nervous system. This has provided a background in all aspects of translation from large animal work through clinical trial completion. Active research interests include the use of small animal epilepsy models to develop and optimize neuromodulation-based candidate therapies for the treatment of medically refractory epilepsy.

Dr. Riley’s additional professional interests include international neurosurgical outreach and program development. .

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Assistant Professor

Neurosurgery State University of New York at Buffalo

Medical Director

Functional Neurosurgery Kaleida Health

Brook Bridge Medical Complex

5959 Big Tree Rd.
Suite 103
Orchard Park, NY 14127

Phone: 716.218.1000

Fax: 716.634.1690


Meet Dr. Jonathan P. Riley


Medical School
Cleveland Clinic Lerner College of Medicine of Case Western Reserve

Emory University Hospital

Thomas Jefferson University Hospital

Clinical Interests

A multidisciplinary treatment approach to the surgical treatment of patients with functional diseases of the nervous system, including:
– Epilepsy
– Movement Disorders (Parkinson’s Disease, Dystonia, Essential Tremor, Spasticity)
– Psychiatric Afflictions (Depression, Obssessive Compulsive Disorder, Tourette’s)
– Treatment refractory cranial and spinal pain syndromes

Additional clinical interests include the treatment of patients with degenerative and oncologic spinal disease.

Professional Highlights

Co-development and preclinical testing of the targeted techniques and technologies that have been utilized in Phase I and Phase II clinical trials evaluating delivery of a cell-based therapeutic to the spinal cord for treatment of patients with Amyotrophic Lateral Sclerosis

Founder of Haiti Neurosurgery Initiative, Inc. This is a non-profit organization that has collaborated with Partners In Health/Zanmi Lasante with the stated goal of longitudinally engaging to support the development of sustainable neurosurgical solutions for the grossly underserved population of Haiti. (https://www.haitineurosurgery.org/).


  • Congress of Neurological Surgery
  • American Association of Neurological Surgery
  • American Epilepsy Society
  • Association of Stereotactic and Functional Neurosurgery

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